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KMID : 0376419850090010017
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Chonbuk University Medical Journal
1985 Volume.9 No. 1 p.17 ~ p.22
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Effects of Indomethacin on the Renal Function in Conscious and Unanesthetized Rabbits
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Kim San-Ho
Cho Kyung-Woo
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Abstract
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To investigate the effect of indomethacin on the renal function, intravenous administration of indomethacin have been done in conscious and unanesthetized rabbits. 1. Intravenous administration of indomethacin, 1 mg . kg-1 of body weight, caused a significant increase of urinary volume, compared with time-control. 2. Glomerular filtration rate was not changed and renal blood flow was slightly increased without significance. 3. Urinary excretion of sodium and chloride was increased, and the fractional excretion of sodium was also increased after intravenous indomethacin. 4. Free water clearance was increased. These results suggest that intravenous administration of indomethacin may cause significant increments of electrolytes excretion and free water clearance by inhibition of sodium reabsorption in the proximal tubule.
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